1.0 OBJECTIVE
To provide the procedure
for the determination
of Piroxicam (20mg)
2.0 SCOPE
This procedure is
Applicable to the determination
of Piroxicam (20mg)
3.0 RESPONSIBILITY
3.1 QC-Chemist
4.0 ACCOUNTABILITY
4.1 Executive – Quality
control
4.2 Head – Quality
control
5.0 PROCEDURE
5.1 Label Claim:
Each dispersible uncoated tablet contains:
Piroxicam IP 20mg
5.2 Assay Method:
5.21 Preparation of
standard solution:
Dissolve 100mg of the Piroxicam in 50ml of methanol and further diluted to 100ml with methanol.
Further dilute 10ml of the above solution into 100ml with methanol.
5.2.2 Preparation of Sample solution:
Weight powder twenty tablets and take the powder equivalent to100mg Piroxicam was accurately weighed, dissolved in 100 ml of methanol, filtered through Whatmann filter paper No: 41.
Further dilute 10ml of the above solution into 100ml with methanol.
5.2.3 Measure the absorbance at about 260nm
5.2.4 Calculate the content by comparison.
Sample absorbance x Standard weight x
Assay x Average weight of the tablet =
Standard absorbance x Sample Weight
x 100
= ____________x100
LC
LC: Label Claim
6.0 ANNEXURES
Nil
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