1.0 OBJECTIVE
To provide the procedure
for the determination of Folic
acid tablets (5 mg)
2.0 SCOPE
This procedure is
Applicable to the determination of Folic
acid tablets (5 mg)
3.0 RESPONSIBILITY
3.1 QC-Chemist
4.0 ACCOUNTABILITY
4.1 Executive – Quality
control
4.2 Head – Quality
control
5.0 PROCEDURE
5.1 Label Claim:
Each uncoated tablet Contains:
Folic acid IP ……………….5mg
5.2 Assay Method:
5.2.1 Preparation of
standard solution:
Dissolve 1.6gm of the Folic acid in 50ml of double distilled water and
further diluted to 100ml with double distilled water. Further dilute 1ml of the
above solution into 10ml with double distilled water.
5.2.2 Preparation of
Sample solution:
Weight powder twenty
tablets and take the powder equivalent to 1.6gm in double distilled water was
accurately weighed, dissolved in 50 ml of double distilled water, filtered
through Whatmann filter paper No: 41 further diluted to 100ml with double
distilled water.
Further dilute 1ml of
the above solution into 10ml with double distilled water.
5.2.3 Measure the absorbance at about 250nm
5.2.4 Calculate the content by comparison.
Sample absorbance x Standard weight x
Assay x Average weight of the tablet =
Standard absorbance x Sample Weight
x 100
= ____________x100
LC
LC: Label Claim
6.0 ANNEXURES
Nil
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