Estimation of Candesartan cilexetil tablets(4/8/16/32mg)

1.0 OBJECTIVE                    

To provide the procedure for the determination of Candesartan cilexetil tablets(4/8/16/32mg)

2.0 SCOPE

This procedure is Applicable to the determination of Candesartan cilexetil tablets(4/8/16/32mg)

3.0 RESPONSIBILITY 

3.1 QC-Chemist 

4.0 ACCOUNTABILITY         

4.1 Executive – Quality control

4.2 Head – Quality control

5.0 PROCEDURE      

    

 5.1 Label Claim: 

Each Tablet Contains:

Candesartan cilexetil         IP  4/8/16/32mg

5.2 Assay Method: 

5.21 Preparation of standard solution:

Dissolve 100mg of the candesartan cilexetil in 50ml of methanol and further diluted to 100ml with methanol.

Further dilute 5ml of the above solution into 100ml with methanol.

5.2.2 Preparation of Sample solution:

Weight powder twenty tablets and take the powder equivalent to100mg candesartan cilexetil was accurately weighed, dissolved in 100 ml of methanol, filtered through Whatmann filter paper No: 41. Further dilute 5 ml of the above solution into 100 ml with methanol.

5.2.3 Measure the absorbance at about 258 nm

5.2.4 Calculate the content by comparison.

Sample absorbance    x  Standard weight  x Assay x Average weight of the tablet = 

Standard absorbance  x  Sample Weight   x   100     

= ____________x100

         LC 

LC: Label Claim

6.0 ANNEXURES

Nil